<output id="v1h5n"><output id="v1h5n"><font id="v1h5n"></font></output></output><output id="v1h5n"></output>
<dl id="v1h5n"></dl>
<dl id="v1h5n"></dl>
<dl id="v1h5n"></dl><dl id="v1h5n"><output id="v1h5n"><font id="v1h5n"></font></output></dl>
<video id="v1h5n"><dl id="v1h5n"></dl></video>
<output id="v1h5n"></output><dl id="v1h5n"><output id="v1h5n"><delect id="v1h5n"></delect></output></dl>
<video id="v1h5n"></video>
<video id="v1h5n"></video>
<video id="v1h5n"></video>
<dl id="v1h5n"><output id="v1h5n"></output></dl>
<dl id="v1h5n"><output id="v1h5n"><font id="v1h5n"></font></output></dl>
<dl id="v1h5n"><output id="v1h5n"></output></dl><dl id="v1h5n"><output id="v1h5n"></output></dl>
<noframes id="v1h5n">
<video id="v1h5n"><dl id="v1h5n"></dl></video>
<noframes id="v1h5n"><output id="v1h5n"><delect id="v1h5n"></delect></output>
<noframes id="v1h5n"><video id="v1h5n"><dl id="v1h5n"></dl></video><video id="v1h5n"><dl id="v1h5n"></dl></video>
<video id="v1h5n"><output id="v1h5n"><output id="v1h5n"></output></output></video>
<noframes id="v1h5n">
<video id="v1h5n"></video>
<video id="v1h5n"></video>
<noframes id="v1h5n"><video id="v1h5n"></video>
新聞詳情

6-羥基多巴胺誘導的帕金森病模型

日期:2022-12-07 11:13
瀏覽次數:347
摘要: 藥品: 6-OHDA HCl :16μg溶解在4μL ACSF中。 ACSF:0.15 M NaCl, 2.75 mM KCl, 1.2 mM CaCl2, and 0.85 mM MgCl2。 動物: 雄性Wistar大鼠,重量300-400g。 建模: 1.大鼠常規麻醉,然后固定在立體定位儀上。 2.暴露大鼠顱骨,在右側內側前腦束(medial forebrain bundle, MFB)上方鉆孔,孔的坐標: (AP), -1.9 mm, (ML), -1.9 mm, (DV),-7.2 mm 。 3. 0.5μL/min,注射4ul,為避免藥物回流,每次輸液完成和拔針之間間隔2分鐘。 模型評估: 1...

藥品:

6-OHDA HCl :16μg溶解在4μL ACSF中。

ACSF:0.15 M NaCl, 2.75 mM KCl, 1.2 mM CaCl2, and 0.85 mM MgCl2。

動物:

雄性Wistar大鼠,重量300-400g。

建模:

1.大鼠常規麻醉,然后固定在立體定位儀上。

2.暴露大鼠顱骨,在右側內側前腦束(medial forebrain bundle, MFB)上方鉆孔,孔的坐標: (AP), -1.9 mm, (ML), -1.9 mm, (DV),-7.2 mm 。

3. 0.5μL/min,注射4ul,為避免藥物回流,每次輸液完成和拔針之間間隔2分鐘。

   

模型評估:

1. 旋轉行為:大鼠皮下注射0.1 mg/kg阿撲mafei,計算15min的總旋轉次數,注射6-OHDA 14天后檢測。

2. 曠場試驗:記錄5min的曠場活動,注射6-OHDA 14天后檢測。

滬公網安備 31011302004470號

免费看久草一级片
<output id="v1h5n"><output id="v1h5n"><font id="v1h5n"></font></output></output><output id="v1h5n"></output>
<dl id="v1h5n"></dl>
<dl id="v1h5n"></dl>
<dl id="v1h5n"></dl><dl id="v1h5n"><output id="v1h5n"><font id="v1h5n"></font></output></dl>
<video id="v1h5n"><dl id="v1h5n"></dl></video>
<output id="v1h5n"></output><dl id="v1h5n"><output id="v1h5n"><delect id="v1h5n"></delect></output></dl>
<video id="v1h5n"></video>
<video id="v1h5n"></video>
<video id="v1h5n"></video>
<dl id="v1h5n"><output id="v1h5n"></output></dl>
<dl id="v1h5n"><output id="v1h5n"><font id="v1h5n"></font></output></dl>
<dl id="v1h5n"><output id="v1h5n"></output></dl><dl id="v1h5n"><output id="v1h5n"></output></dl>
<noframes id="v1h5n">
<video id="v1h5n"><dl id="v1h5n"></dl></video>
<noframes id="v1h5n"><output id="v1h5n"><delect id="v1h5n"></delect></output>
<noframes id="v1h5n"><video id="v1h5n"><dl id="v1h5n"></dl></video><video id="v1h5n"><dl id="v1h5n"></dl></video>
<video id="v1h5n"><output id="v1h5n"><output id="v1h5n"></output></output></video>
<noframes id="v1h5n">
<video id="v1h5n"></video>
<video id="v1h5n"></video>
<noframes id="v1h5n"><video id="v1h5n"></video>